This post represents an excellent opportunity for a medically qualified trainee with an interest in metabolism to join a multidisciplinary team of clinical and basic scientists investigating adipose tissue function/dysfunction (in the context of lipodystrophy and obesity) and its consequences, including non-alcoholic fatty liver disease, insulin resistance and type 2 diabetes. The group undertakes detailed human metabolic studies in patients with severe insulin resistance due to lipodystrophy or other causes, and also uses both cellular and animal models (particularly mice) to understand the molecular consequences of nutritional overload.
The successful candidate will play a key role in undertaking human studies, including detailed analysis of energy balance/energy expenditure, insulin sensitivity, adipose and muscle tissue sampling/analysis, and MR imaging and spectroscopy. They will also be involved in cellular studies in the lab and possibly in related animal model work.
The post is ideally suited to clinicians who have already some previous experience in these areas but this is not essential. There is scope for appropriate candidates to use this opportunity to register for a higher degree (PhD or MD) and apply for Honorary Clinical status.
A knowledge of Good Clinical Practice (GCP) and the Human Tissue Act (HTA) is expected and experience with ethics applications would be very helpful.
The role holder will be responsible for running their own research projects and will work with a small group of post docs and PhD students who have overlapping expertise.
Responsibilities are likely to include: ¿ Setup, participant recruitment, and running of human investigative medicine studies (including handling of HTA material) ¿ Detailed human metabolic phenotyping ¿ Cell culture, cloning, transfection, site-directed mutagenesis ¿ Confocal imaging ¿ Big data analysis ¿ RNAseq etc
Closing date: 14 June 2023 Interview date: TBC Proposed start date: As soon as possible
- Fixed Term: The post is available for 3 years in the first instance
Informal enquiries about this post may be directed to Prof David Savage at [email protected] or via 01223 767923
Fixed-term: The funds for this post are available for 3 years in the first instance.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. This appointment also requires an Honorary Clinical Contract.
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Please ensure that you upload a covering letter, CV and Additional Information form in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Please quote reference RG36694 on your application and in any correspondence about this vacancy.
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