We are looking for a talented and motivated full-time research assistant to join the group of Dr William Grey based in the York Biomedical Institute, Department of Biology at the University of York. The Grey lab focuses on the proteome and the roles of protein homeostasis in healthy haematopoiesis and malignant transformation to acute myeloid leukaemia (AML), with a particular interest in using primary patient material and translating fundamental biological findings to therapeutic targeting. The post is full time, on a fixed term basis for an initial 12 month period with an extension available.
We study the leukaemic stem cell (LSC) compartment of AML using both inducible mouse models (Cancer Cell 2016) and primary patient samples (Sci. Transl. Med. 2022), with a particular focus on the functional state of the proteome (Blood 2020). In this new project, funded by the MRC, Children’s Cancer and Leukaemia Group and Leukaemia U.K., we will study how the proteome evolves from healthy haematopoietic stem cell to malignant leukaemic stem cell in vivo.
The successful candidate will benefit from a highly collaborative programme with academic and clinical interactions in the U.K. and Europe including; Prof. David Kent (York, U.K., HSC biology), Dr. Anjum Kahn (Leeds, U.K., Consultant haematologist), Prof. Cristina Lo Celso (London, U.K., in vivo imaging), Dr. Andrew Wood (Edinburgh, U.K., degron tagging), Prof. Jurg Schwaller (Basel, Switzerland, inducible mouse models) and Dr. Marieke Essers (Heidleburg, Germany, HSC stress integration). The post holder will also benefit from a multidisciplinary environment locally at the Centre for Blood Research (Kent, Hitchcock, Bridge) and colleagues in Chemistry (Fascione, Spicer). The post holder will be expected to balance driving research projects alongside managing mouse models and xenograft cohorts, as well as ordering and stocking the lab . They will also work closely with other lab members and researchers across the institute.
- The successful candidate will have at least an undergraduate degree in a biomedical sciences discipline, or equivalent experience in haematology, immunology or cancer cell biology.
- Experience in cell culture and molecular biology techniques (e.g. PCR, qPCR, western blotting and flow cytometry) are desirable.
- Experience in using in vivo mouse models, primary stem cell cultures, primary human material and proteomics are particularly encouraged to apply.
The post is full time on a fixed term basis of 12 months with an extension available. Salary is dependent on experience and qualification of the successful candidate.
Interview date: To be confirmed
For informal enquiries: please contact Dr William Grey at [email protected]
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We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
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