Laboratory Technician in Cell Biology and Genetics
Regulation and activities of amyloidogenic APP and TGFBI in physiological and pathological protein aggregation
Full-time/Fixed Term until 31 March 2025 (in the first instance)
Applications are invited for a Laboratory Technician position to work on a project to determine the mechanisms regulating protein aggregation and amyloidogenesis, using a new live-cell model developed in the fruit fly, Drosophila melanogaster. Amyloid accumulation is associated with several major human diseases, most notably neurodegenerative disorders. The post-holder will join Professor Clive Wilson’s group, which has recently shown that homologues of two human proteins implicated in pathological amyloidogenesis, Amyloid Precursor Protein (APP; Alzheimer’s Disease) and Transforming Growth Factor-Beta-Induced (TGFBI; corneal dystrophies) have normal roles in protein aggregation. They will support research to understand how normal protein aggregation is controlled and how it differs from pathological amyloid formation, and undertake experiments to find new genes controlling these two processes.
Duties of the role include assisting with planning and undertaking experiments, processing samples and specimens and writing up experimental results. The post-holder will ensure smooth day-to-day running of the laboratory, assist with fly stock maintenance, and maintain databases of equipment, consumables and/or fly stocks. They will assist with inductions and be a point of reference for less experienced team members.
To apply, they must have laboratory experience, knowledge of safety regulations and an enthusiasm for research. They must also be educated to at least A-level or equivalent qualification in science, and have good interpersonal and communication skills.
The post is available from 1 September 2023. It is jointly funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Medical Research Council (MRC), and will be based in The Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Rd, Oxford OX1 3PT.
Closing date for applications is midday on Monday 12 June. Interviews are likely to be held in the week beginning 26 June.
Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford. While this is a full-time role, we welcome applications from individuals who seek flexible working arrangements.
We, as a Department and Community, will be considerate and welcoming of all people, regardless of race, ethnicity, religion, disability, sexual orientation and gender identity. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion