Do you feel passionate about the possibilities of science to change lives? Do you have a background in analytical science / biochemistry and a drive to deliver data that directly impacts drug discovery and development projects? If so, this may be the role for you. We currently have an exciting opportunity for a highly motivated bioanalytical scientist to join our DMPK team.
AstraZeneca
AstraZeneca is a global biopharmaceutical company driven by what science can do. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. Our vision is to be at the forefront of developing the new generation of cancer therapies.
Oncology R&D DMPK department
The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/PK, as well as translational PK/PD Modelling & Simulation support to all modalities in our discovery and development portfolio.
Be part of fulfilling our ambition to be world leaders in Oncology. Oncology R&D is a major focus area and growth platform at AstraZeneca, and there are countless new indications and targets in our pipeline. By leveraging our commercialised portfolio, we are confident we can change the practice of medicine and redefine cancer treatment. We’re brave disruptors – entrepreneurial, courageous, and pioneering in our approach. Here you can step up, take personal accountability, and lead changes in our ever-evolving environment.
What you’ll do
You will join a lab based team of DMPK scientists that supports our diverse portfolio including small molecules, PROTACs, antibody drugs conjugates (ADCs) and nanomedicines. The qualified candidate will deliver quantitative bioanalysis for oncology pharmacology and pharmacokinetic studies during drug discovery and development, maintaining close collaboration between oncology DMPK and Bioscience. The position is based in Cambridge (UK).
Accountabilities
Providing quantitative LC-MSMS bioanalysis for in-vivo pharmacology and PK studies (non GLP)
Delivering analytical solutions for small molecules including beyond rule of five compounds
Taking a leading role in the lab designing bioanalysis method strategies
Interpreting and communicating data generated to support projects
Maintaining and progressing internal data processing tools (NCA)
Tutor / mentor early career scientists (no direct line management responsibility)
Recommending and supporting innovations within the discipline
Contributing to publishing papers in internationally recognised journals
Minimum Requirements – Education, Experience and Capabilities
first degree in a relevant scientific discipline ideally followed by PhD or equivalent experience as bioanalytical scientist.
The ability to develop hypotheses and execute analysis plans for pharmacokinetic studies
Experience in data interpretation for DMPK
Extensive experience and expertise in several of the following:
LC-MS/MS method development and problem solving for quantitative bioanalysis
Experience in troubleshooting analytical and equipment issues
Non-compartmental analysis of pharmacokinetic data
Bioanalytical and PK data management skills
Biological sample extraction and preparation techniques
Excellent interpersonal skills that lead to successful collaborative work-relationships
Location: Cambridge, UK
Cambridge Site location
Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…
Where life meets Science…Chesterford Research Park offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.
This role will then relocate to the Cambridge Biomedical Campus, when the site is completed - this site combines world-class biomedical research, patient care and education on a single site location in the heart of Cambridge.
Competitive salary and benefits package on offer.
The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.
Why AstraZeneca?
At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth, and development. We’re on an exciting journey to pioneer the future of healthcare.
So, what’s next?
If you are already imagining yourself joining our team. Good, because we can’t wait to hear from you!
Where can I find out more?
Reach out to connect with our recruiter - Sophie Halpin - via LinkedIn on:
https://www.linkedin.com/in/sophie-beverley-halpin/ for a confidential discussion to explore how this role could be your next career move