Site Name: UK - Hertfordshire - Stevenage
Posted Date: Jan 27 2023
The structural biology and biophysical department in Stevenage continues to grow. Already supporting small molecule and biotherapeutics we are adding a new team to concentrate on structural vaccinology working in close collaboration with vaccine research sites in Italy, Belgium and the US.
This role provides a fantastic opportunity for talented structural biologists, particularly those with cryo-EM expertise and an interest in vaccine development to join this vibrant department on a permanent, full-time basis.
The UK Structural & Biophysical Sciences group is a multi-disciplinary department within GSK R&D that provides molecular insights into medicine discovery for small molecule, biopharmaceutical and now vaccine programs. We are founding members of the Cambridge Pharmaceutical cryo-EM consortium with access to two state-of-the-art ThermoFisher maintained Krios systems. In house our EM suite with a Glacios with a Falcon 4i will soon be joined by an additional Glacios2. Together with Leica and Vitrobot sample preparation stations, high-performance computing infrastructure and an array of biophysical techniques (mass photometry, structural mass spectrometry, FIDA, SPR) the department works in unison and across many modalities to generate molecular insights that help progress projects from concept to medicines.
We are looking for group members with demonstrated success in structural biology including cryo-EM ideally applied to vaccine or antibody research to join this new group. To be successful you will have broad knowledge and practical expertise in single particle cryo-EM, cryo-ET or X-ray crystallography, especially on membrane protein targets. Motivated to work within a team environment you will want to apply your talents to drive impact on drug discovery projects by working closely with others. With a passion to remain current in this rapidly moving area, you are likely to have exceptional strengths in one ore more specific aspects of EM. Whether this be instrument knowledge, challenging sample optimisation, skills in software development and processing, or creativity in addressing complex problems, we are keen to understand the abilities that set you apart!
Recognising the value of maintaining excellence GSK supports individual career paths and personal development planning. Our goal is to build diverse teams that work together to address key drug discovery challenges with the best scientific insights possible.
In this role you will
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Deliver structural data and insights across global portfolio of vaccine projects to inter-disciplinary teams.
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Liaise and consult as a structural & biophysics representative to vaccine program teams.
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Manage interactions with multiple projects and be influential in prioritize across your individual and the wider department activities
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Maintain scientific excellence in a rapidly evolving area e.g. through interactions such as the ThermoFisher/LMB/Pharma consortium.
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Maintain connectivity with external science community to stay abreast of science developments.
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Act as an ambassador for GSK science externally through publications and scientific engagement.
Why you?
Qualifications & Skills:
We are looking for professionals with these required skills to achieve our goals:
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Background in a biological, biochemical, or physical sciences discipline, with PhD level or equivalent experience.
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Knowledge of all stage’s single particle cryo-EM process from protein purification to grid optimisation, data-processing, 3-D reconstruction, and structure interpretation.
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Demonstrated exceptional track record of success and expertise in at least one specific area of the cryo-EM process.
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Experience with the operation of screening and high-resolution data-collection microscopes.
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Success with high-resolution structure determination especially of small proteins, membrane proteins, or antibody/antigen complexes.
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Excellent organisational skills.
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Strong interpersonal, communication and team working skills.
Preferred Qualifications & Skills:
If you have the following characteristics, it would be a plus:
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Postdoctoral/industrial experience in structural biology.
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Strong track record of publications in peer reviewed journals, or patent filing
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Interest in vaccine and antibody research
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Ability to integrate EM data with data from other biophysical techniques.
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Experience with protein expression and purification, particularly membrane proteins.
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Practical expertise in cryo-ET, X-ray or other biophysical methods.
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Experience of scientific leadership to influence programs of research.
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Ability to coordinate projects with interconnecting activities.
Closing Date for Applications: 17th February 2023 (COB)
Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.
During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
Why GSK?
Uniting science, technology and talent to get ahead of disease together
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
Find out more:
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R&D
We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.
In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.
Find out more:
Our approach to R&D
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.
As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).
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