Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has not yet been awarded their PhD, the starting salary will be at £34,344 until the successful completion of their viva.
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.
Duration of Contract: Fixed Term for 2 years
Hours per week: 35 hours per week (Full Time)
Closing Date: 20TH March 2023
Under the leadership of Dr Alejandra Bruna, we are seeking to appoint a Postdoctoral Training Fellow to join the Preclinical Modelling of Paediatric Cancer Evolution team. This role involves the candidate to perform research into cancer evolution, which will require the development and application of new experimental assays and/or computational methods.
For general information on Post Doc's at The ICR can be found here.
Key Requirements
The successful candidate must meet the following criteria:
- PhD in quantitative or biological subject, or likely to be awarded PhD in the near future.
- Undergraduate degree in biological or quantitative subject.
- Appropriate publication in the subject area for career stage
- Ability to interpret the scientific literature and incorporate this into the project
- Proven ability to work effectively in an interdisciplinary team
- Proven ability to maintain accurate and up to date records
Please refer to the attached PDTF job description pack where all essential, and desirable, criteria is listed.
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years
Directorate Information:
The Centre for Evolution and Cancer (CEC), within the Division of Molecular Pathology, is a multidisciplinary centre, comprising around 40 staff dedicated to understanding cancer evolution and leveraging this knowledge for translational benefit. Our interests span early detection through to treatment of metastatic disease. The CEC brings together expertise in evolutionary theory, computational biology and bioinformatics together with cutting-edge research ability in cell and molecular biology to provide a stimulating and creative interdisciplinary environment where new approaches to tackling cancer can thrive.
https://www.icr.ac.uk/our-research/centres-and-collaborations/centres-at-the-icr/centre-for-evolution-and-cancer
Department Information:
The Preclinical Modelling of Paediatric Cancer Evolution team (PCE team) led by Dr. Alejandra Bruna is interested in studying the molecular mechanisms underlying paediatric cancer evolutionary processes leading to therapy resistance and relapse.
We are based at the ICR Sutton site within the Centre for Evolution and Cancer, located in the outstanding facilities of the newly opened Centre for Cancer Drug Discovery building.
Recent evidence suggesting a major role of cell plasticity and epigenetic rewiring in therapeutic resistance has sparked interest on the role of non-genetic evolution during cancer progression. Our main goal is to identify plasticity, hereditability and cell state dynamics using paediatric cancer models representative of the disease in patients. To this end we are using and developing innovative technologies that couple scRNA-seq and cell ancestry information. We predict a better understanding into these processes is a recipe to identify novel treatment strategies using evolutionary steering of plasticity which may lead tumours to extinction.
You will be joining a highly diverse and interdisciplinary team of about 7 people, consisting of biologists and computational scientists. Our ideal candidate will have previous computational modelling experience and a keen interest in cancer evolution and genomics and strong quantitative skills. You will be co-supervised by Professor Trevor Graham (Director of the Centre for Evolution and Cancer) and head of the Genomics and Evolutionary Dynamics team which combine molecular and cellular biology together with mathematical and computational modelling to study the evolution of malignancy.
This project is also shared with Professor Janet Shipley (Division Head of Molecular Pathology)
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Alejandra Bruna via email on [email protected] (Please DO NOT send your application to Dr Alejandra Bruna, but apply via the e-recruitment system on our website www.icr.ac.uk)
Why work for us?
As a member of staff, you'll have exclusive access to a range of staff benefits.
The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.
We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.